There are many factors influencing yields in extraction. The first article in this three-part series presented a review of starting-material influence on extraction yields: the amount of starting material added to an extraction chamber, in addition to the content of compounds of interest intrinsic to that material, are important (1). Next, part II examined the effects of material preparation: a finer particle size provides better packing efficiency, as well as greater efficiency of solvent-matrix interactions (2). Here, the final installment reviews the influence of operating conditions, elucidating how extraction runtime and processing parameters affect yields in extraction.